P-28: Protective Effect of Curcumin on The Damages Induced by Nicotine on Reproductive Parameters in Male Mice

Background: Nicotine is a substance that can induce oxidative stress in the testes. And thus may reduce fertility in men. Antioxidant supplements such as curcumin can reduce oxidative stress and thus may increase fertility in men. Since the most active component responsible for the yellow color of turmeric and curcumin has anti-inflammatory and antioxidant properties. Therefore this study investigated the protective effect of curcumin against nicotine-induced damage on reproductive parameters in male mice explains. Materials and Methods: In this study, 56 male mice received 8 + ethanol, ethanol + nicotine + curcumin saline and three doses of 10, 30 and 60 mg nicotine + curcumin (10, 30, 60) into Vdvz 2.5 mg of nicotine is injected intraperitoneally at 28 days was done. Later, the mice were anesthetized and dissected WHO sperm parameters were measured according to the method. Results: Nicotine can significantly induce oxidative stress in the testes and other curcumin could significant ly reduces oxidative stress and enhances fertility. Conclusion: Anti-inflammatory and antioxidant effects of curcumin results in infertility treatment is approved.